How Veeda is Advancing Next-Generation Bioanalysis with SFC-MS/MS

Faster Turnaround, Greener Science, and Smarter Drug Quantification

As pharmaceutical and biotechnology companies continue to accelerate drug development timelines, the demand for faster, more sensitive, and environmentally sustainable bioanalytical solutions has never been greater. Traditional analytical platforms have served the industry well for decades, but emerging technologies are now enabling laboratories to achieve higher throughput, improved analytical performance, and reduced environmental impact simultaneously.

At Veeda Lifesciences, innovation remains central to delivering world-class bioanalytical services. Strengthening its next-generation analytical capabilities, Veeda has successfully implemented Supercritical Fluid Chromatography coupled with Tandem Mass Spectrometry (SFC-MS/MS), a transformative technology that is redefining the future of bioanalysis.

This strategic investment allows Veeda to provide faster analytical turnaround times, improved chromatographic performance, sustainable laboratory operations, and highly sensitive drug quantification for pharmaceutical development programs worldwide.

Veeda Showcases SFC-MS/MS Expertise on a Global Platform

Demonstrating its commitment to scientific innovation and green chemistry, We recently presented its advanced SFC-MS/MS capabilities at the SFC/SFE Japan 2026 – Green Chemistry for Sustainability conference held at the Shimadzu Tokyo Innovation Plaza, Japan.

Representing Veeda, Dr. Chirag Patel, Lead Scientist Bioanalytical Research, highlighted the organization’s successful implementation of SFC-MS/MS technology and its application in solving complex bioanalytical challenges.

The presentation showcased our ability to develop and transfer sophisticated bioanalytical methods while simultaneously improving efficiency, sensitivity, and sustainability.

Understanding SFC-MS/MS: The Next Evolution in Bioanalysis

Supercritical Fluid Chromatography (SFC) uses supercritical carbon dioxide as the primary mobile phase, often combined with small amounts of organic modifiers. When coupled with Tandem Mass Spectrometry (MS/MS), the technology provides highly sensitive quantitative analysis with significantly faster chromatographic separation compared to conventional liquid chromatography methods.

The technology offers unique advantages for:

• Chiral compound analysis
• New Chemical Entity (NCE) characterization
• Metabolite quantification
• Complex biomarker analysis
• High-throughput bioanalysis
• Environmentally sustainable analytical workflows

Unlike traditional LC-MS/MS systems that rely heavily on organic solvents, SFC-MS/MS dramatically reduces solvent consumption while maintaining exceptional analytical performance.

Successfully Solving Complex Bioanalytical Challenges

Veeda Lifesciences has successfully established and transferred multiple challenging analytical methods using SFC-MS/MS technology, demonstrating its capability to address complex pharmaceutical development requirements.

Accelerated Chiral NCE Analysis

Chiral analysis remains one of the most challenging areas in bioanalytical research. Many new chemical entities require accurate separation of stereoisomers to ensure proper characterization and regulatory compliance.

Using SFC-MS/MS technology, Veeda successfully developed analytical methods for chiral NCEs while achieving:

• Up to 40% reduction in analytical runtime
• Improved chromatographic resolution
• Enhanced peak symmetry
• Increased laboratory throughput
• Improved method efficiency

These improvements enable faster decision-making during drug development while maintaining analytical quality and scientific rigor.

Estradiol and Estrone Method Transformation

One of the most significant demonstrations of our SFC-MS/MS expertise involved the successful transfer of a complex estradiol and estrone bioanalytical method from conventional LC-MS/MS to SFC-MS/MS.

The results were remarkable.

The optimized SFC-MS/MS method successfully achieved:

• Simultaneous separation of estradiol and estrone
• Excellent chromatographic performance
• High analytical robustness
• Quantification sensitivity at the 1 pg/mL level

This achievement demonstrates the capability of SFC-MS/MS to handle highly challenging endogenous biomarker analyses while significantly reducing analytical turnaround time.

Key Advantages of SFC-MS/MS at Veeda

The implementation of SFC-MS/MS technology delivers substantial benefits across multiple dimensions of bioanalytical operations.

1. Faster Analytical Turnaround

Speed is critical in modern drug development.

By reducing analytical runtime by more than 40% for many applications, SFC-MS/MS enables:

• Faster sample processing
• Increased batch capacity
• Improved laboratory productivity
• Reduced project timelines
• Accelerated clinical study support

For sponsors, this translates directly into faster access to critical bioanalytical data.

2. High-Throughput Bioanalysis

SFC-MS/MS systems can operate at flow rates up to 5 mL/min, enabling rapid chromatographic separations without compromising data quality.

Benefits include:

• Increased sample throughput
• Greater laboratory efficiency
• Enhanced scalability for large studies
• Reduced instrument occupancy

This capability is particularly valuable for late-phase clinical studies requiring analysis of thousands of biological samples.

3. Superior Chromatographic Performance

Analytical performance remains a cornerstone of successful bioanalysis.

SFC-MS/MS provides:

• Improved chromatographic resolution
• Better peak symmetry
• Enhanced selectivity
• Reduced matrix interference
• Improved method robustness

These attributes contribute to more reliable quantification and greater confidence in analytical results.

4. Exceptional Sensitivity

For many modern drug development programs, ultra-low level quantification is essential.

We demonstrated ability to quantify estradiol and estrone at concentrations as low as 1 pg/mL highlights the sensitivity potential of the platform.

Such performance supports:

• Pharmacokinetic studies
• Endogenous biomarker assessments
• Hormone analysis
• Low-dose drug quantification
• Advanced translational research

Driving Sustainability Through Green Chemistry

Beyond analytical performance, one of the most compelling advantages of SFC-MS/MS is its contribution to environmentally sustainable laboratory operations.

Significant Reduction in Solvent Consumption

Traditional chromatographic methods often require substantial volumes of organic solvents.

By utilizing supercritical carbon dioxide as the primary mobile phase, Our SFC-MS/MS workflows achieve:

• 70–80% reduction in organic solvent consumption
• Lower hazardous waste generation
• Reduced solvent procurement requirements
• Lower environmental impact

Reduced Equipment Contamination

Lower solvent usage also contributes to operational efficiency by:

• Minimizing system contamination
• Reducing maintenance requirements
• Decreasing instrument downtime
• Improving system longevity

These benefits further enhance laboratory productivity while supporting sustainable operations.

Responsible Use of Recycled Carbon Dioxide

An additional environmental advantage comes from the use of recycled industrial carbon dioxide as the primary mobile phase component.

This approach aligns with global green chemistry initiatives by:

• Reducing dependence on traditional solvents
• Supporting resource efficiency
• Lowering laboratory environmental footprint
• Promoting sustainable analytical science

Strategic Investment in Next-Generation Bioanalysis

Recognizing the growing importance of advanced analytical technologies, Veeda continues to proactively invest in state-of-the-art bioanalytical infrastructure.

As part of its long-term innovation strategy, We have successfully installed five SFC-MS/MS systems across its facilities.

This investment reinforces our commitment to:

• Accelerated bioanalytical workflows
• High-throughput analytical services
• Advanced method development
• Sustainable laboratory practices
• Green chemistry adoption
• Scientific excellence

The expanded SFC-MS/MS infrastructure positions ourselves to support increasingly complex pharmaceutical and biotechnology development programs worldwide.

The Future of Bioanalysis is Faster, Smarter, and Greener

As drug molecules become more complex and development timelines continue to shorten, the bioanalytical industry must evolve to meet new scientific and operational challenges.

SFC-MS/MS represents a significant advancement in analytical science by combining:

• High sensitivity
• Rapid analysis
• Improved chromatographic performance
• Reduced environmental impact
• Greater laboratory efficiency

Through continuous investment in innovative technologies such as SFC-MS/MS, we remains committed to delivering scientifically robust, operationally efficient, and environmentally sustainable bioanalytical solutions that support the successful development of tomorrow’s medicines.

As the pharmaceutical industry increasingly embraces sustainability alongside scientific excellence, Veeda Lifescience’s next-generation bioanalytical capabilities are helping shape the future of drug development.